At Orleans Family Health Clinic, we understand how frustrating it can be to live with unexplained exhaustion, brain fog, and pain—especially when your symptoms are dismissed or misunderstood.

Now, new research from the University of Edinburgh is helping to validate what many patients with ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) have known for years: this is a real, biological illness, and it leaves a fingerprint in your blood.

In the largest biological study of its kind—analyzing data from over 130,000 people—researchers found consistent blood differences in people with ME/CFS, linked to inflammation, insulin resistance, and liver dysfunction. These findings bring hope for the development of a future diagnostic blood test, something patients and clinicians alike have been waiting for.

One of the key symptoms of ME/CFS is post-exertional malaise (PEM)—a severe crash in energy following even minor activity. Other symptoms include:

• Brain fog
• Pain
• Sleep that doesn’t restore
• Deep, persistent fatigue

The study’s lead researcher, Prof. Chris Ponting, stated: “For so long people with ME/CFS have been told it’s all in their head. It’s not. We see it in their blood.”

While some experts urge caution in interpreting the findings, the evidence adds significant weight to the call for greater medical recognition, research funding, and compassionate care.

At Orleans Family Health Clinic, we stand with patients affected by chronic fatigue. If you’ve been struggling with unexplained fatigue or have questions about ME/CFS, speak with your healthcare provider.

Disclaimer: The medical information on this site is provided as an information resource only and is not to be used or relied on for any diagnostic or treatment purposes. This information does not substitute for professional diagnosis and treatment. Please do not initiate, modify, or discontinue any treatment, medication, or supplement solely based on this information. Always seek the advice of your healthcare provider first. Full Disclaimer.