How Severe Influenza Can Damage the Heart: New Research Insights
As flu season kicks in, most of us focus on common symptoms like fever, cough, and fatigue, but did you know that severe influenza can also directly harm the heart? Recent research is shedding light on why heart attacks are more frequent during flu season.
What the Research Found
Researchers at the Icahn School of Medicine at Mount Sinai studied tissue samples from patients who died of influenza and discovered a surprising mechanism. A type of immune cell, called pro-dendritic cell 3, becomes infected in the lungs during severe flu. Instead of fighting the virus, these cells travel to the heart and produce large amounts of an inflammatory protein called type 1 interferon (IFN-1). This triggers the death of heart muscle cells, reducing the heart’s pumping ability.
Dr. Filip Swirski, study leader, explains, “The pro-dendritic cell 3 acts as the ‘Trojan horse’ of the immune system during influenza infection, spreading inflammation to the heart.” Laboratory studies showed that controlling IFN-1 activity using an experimental mRNA therapy reduced heart muscle damage in test tubes and animal models, pointing to potential future treatments.
Why Flu Vaccination Matters
Importantly, flu vaccination offers some protection against this type of cardiac damage, reinforcing the need to get vaccinated each season, especially for those with underlying heart conditions.
These findings highlight a key takeaway: influenza isn’t just uncomfortable. It can be dangerous for the heart. Protecting yourself with vaccination and prompt medical attention for severe symptoms remains essential.
Takeaway for Patients
- Get your annual flu shot.
- If you have heart disease, take extra precautions during flu season.
- Seek medical attention promptly if flu symptoms are severe or worsening.
At OFHC, we are committed to keeping our community informed about emerging health risks and preventive strategies.
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